Mononuclear cell secretome in autoimmune myocarditis
نویسندگان
چکیده
منابع مشابه
Mononuclear cell secretome in autoimmune myocarditis.
Myocarditis is defined as inflammation of cardiac muscle with or without myocyte necrosis. Both infectious and non-infectious aetiologies for myocarditis are known, but the most common is virus-induced myocarditis often followed by post-infectious inflammatory cardiomyopathy. Many RNA (picorna-, orthomyxo-, paramyxo-, and flaviviruses) as well as DNA (adeno-, erythro-, herpes-, and retroviruses...
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AIMS Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia. Inflammatory dilated cardiomyopathy (iDCM) is a common cause of heart failure in young patients. Experimental autoimmune myocarditis (EAM) is a CD4+ T cell-dependent model, wh...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2013
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/eht050